<html><head></head><body style="overflow-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;">README.txt<div><br><div><div>Signal to Symptom: Biochemistry Mechanisms to Clinical Phenotypes v1.0</div><div><br></div><div>Overview</div><div>This dataset maps core biochemistry concepts to translational reasoning fields:</div><div>core mechanism, failure mode, observable pattern, and phenotype-level context.</div><div>It is structured for teaching, study workflows, and concept-integration exercises.</div><div><br></div><div>Data dictionary</div><div>- concept_name: Canonical concept label.</div><div>- core_mechanism: Core biochemical process in one concise sentence.</div><div>- failure_mode: Plausible disruption of that process.</div><div>- observable_pattern: Expected experimental or conceptual signal.</div><div>- clinical_phenotype: High-level phenotype context (non-diagnostic framing).</div><div>- topic_cluster: Thematic instructional grouping.</div><div>- confidence_level: Foundational, Intermediate, or Advanced.</div><div>- source_type: Provenance label for curation source.</div><div><br></div><div>Intended use</div><div>- Course-aligned review and teaching</div><div>- Flashcard and quiz generation</div><div>- Concept mapping and knowledge-graph seeding</div><div>- Introductory translational reasoning practice</div><div><br></div><div>Not intended for</div><div>- Diagnosis</div><div>- Treatment decisions</div><div>- Clinical guideline replacement</div><div><br></div><div>References (APA 7th)</div><div>Berg, J. M., Tymoczko, J. L., Gatto, G. J., Jr., &amp; Stryer, L. (2019). Biochemistry (9th ed.). W. H. Freeman.</div><div>Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680–685.</div><div>Lineweaver, H., &amp; Burk, D. (1934). The determination of enzyme dissociation constants. Journal of the American Chemical Society, 56(3), 658–666.</div><div>Michaelis, L., &amp; Menten, M. L. (1913). Die Kinetik der Invertinwirkung. Biochemische Zeitschrift, 49, 333–369.</div><div>Nelson, D. L., &amp; Cox, M. M. (2021). Lehninger principles of biochemistry (8th ed.). W. H. Freeman.</div><div>Perutz, M. F. (1970). Stereochemistry of cooperative effects in haemoglobin. Nature, 228, 726–739.</div><div>Rodwell, V. W., Bender, D. A., Botham, K. M., Kennelly, P. J., &amp; Weil, P. A. (2021). Harper’s illustrated biochemistry (32nd ed.). McGraw Hill.</div><div>Towbin, H., Staehelin, T., &amp; Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proceedings of the National Academy of Sciences, 76(9), 4350–4354.</div><div><br></div><div>Suggested citation</div><div>Zhao, K. (2026). Signal to Symptom: Biochemistry Mechanisms to Clinical Phenotypes v1.0 [Data set]. Harvard Dataverse.</div><div><br></div><div>License</div><div>CC BY 4.0</div></div><div><br></div></div></body></html>